We invite you to join us for a brand new webinar series!  The Early Career Showcase Webinar Series launches on January 21 with the first of three exciting sessions, spotlighting early-career scientists and their research.

This webinar series is dedicated to highlighting and celebrating the contributions of early-career researchers, showcasing their innovative work, and fostering connections within the scientific community.

Are Current Rat Studies Sensitive to Detect Blood Pressure Changes per the New FDA Draft Clinical Blood Pressure Guidance?
Kamila Sadko, Michigan State University, East Lansing, MI, USA
This webinar will discuss the utility of preclinical rodent studies in detecting and determining drug-induced blood pressure elevations in relation to the FDA draft clinical guidance titled “The Assessment of Pressor Effects of Drugs.” It seeks to provide a look into the early career safety pharmacology research going on in the academic sphere.

Evaluation of the Sensitivity/Specificity of Statistical Analysis Strategies for Detecting Moxifloxacin-Induced QTc Prolongation

Larry Carey, Charles River Laboratories, Mattawan, MI, USA
In light of the implementation of the best practice guidelines as outlined in the ICH E14/S7B Q&A’s, several strategies for enhancing the sensitivity of statistical analyses to detect drug-induced QT/QTc prolongation have been proposed. The results of the study to be presented in this webinar evaluated the sensitivity and specificity of several commonly used statistical analysis strategies for detecting alterations in cardiovascular endpoints assessed on cardiovascular telemetry studies, including QTc.

Rodent Models of Anxiety and Compulsion: When Multiple Endpoints Add Value
Justyna Glazar, Labcorp Early Development Ltd., Harrogate, United Kingdom
This presentation will highlight the advantages of using a battery of behavioral tests to assess the anxiolytic, anxiogenic, and anti-compulsive effects of various compounds in rodents. The key findings demonstrate how assessing multiple endpoints—such as anxiety-like behaviors (e.g., light/dark box) and compulsive behaviors (e.g., marble burying, nestlet shredding)—provides a more comprehensive understanding of drug effects.

Tuesday, January 21 at 11:00 AM ET

*Registration for all attendee types is free for this webinar

Moderator: Raafat Fares, PhD, ERT, ERBC (Training & Education Committee Chair)